Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike DynamicsArticle Published on 2023-02-282023-07-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), [키워드] glycosylation mass spectrometry molecular dynamics SARS-CoV-2 Variant of concern. [DOI] 10.1016/j.jmb.2022.167928 PMC 바로가기
An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Mass spectrometry detection of monkeypox virus: Comprehensive coverage for ranking the most responsive peptide markersArticle Published on 2023-01-012023-06-09 Journal: Proteomics [Category] 원숭이두창, [키워드] detection DIA markers mass spectrometry Monkeypox proteomics virus. [DOI] 10.1002/pmic.202200253 PMC 바로가기
Translation landscape of SARS-CoV-2 noncanonical subgenomic RNAsArticle Published on 2022-12-012023-07-10 Journal: Virologica Sinica [Category] COVID19(2023년), [키워드] mass spectrometry RNA binding SARS-CoV-2 Subgenomic RNA (sgRNA) translation. [DOI] 10.1016/j.virs.2022.09.003 PMC 바로가기
Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid TreatmentArticle Published on 2022-10-112022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] acquisition Amino acid analysed Analysis arginine caused Cohort Concentration COVID-19 COVID-19 infection COVID-19 infections COVID-19 pathogenesis dataset degranulation Dexamethasone dysregulation effective feature glucocorticoid Glucocorticoid treatment Glucocorticoids Guidance highlight include indicated Interaction mass spectrometry metabolomics modulation mortality rates Multi-omics neutrophil oxygen supplementation pandemic Partial participant pathway Pathway analysis Patient Platelet proteomics proteomics. Quantitative serum statistically significant Treatment treatment regimen tyrosine was performed [DOI] 10.3390/ijms232012079 PMC 바로가기
Evaluation of Variant-Specific Peptides for Detection of SARS-CoV-2 Variants of ConcernArticle Published on 2022-10-072023-07-10 Journal: Journal of Proteome Research [Category] COVID19(2023년), [키워드] COVID-19 mass spectrometry peptides proteomics SARS-CoV-2 SARS-CoV-2 variants variants of concern Viral proteins. [DOI] 10.1021/acs.jproteome.2c00325 PMC 바로가기
A UPLC-MS/MS Method for Plasma Biological Monitoring of Nirmatrelvir and Ritonavir in the Context of SARS-CoV-2 Infection and Application to a CaseCase Reports Published on 2022-10-052023-07-10 Journal: Journal of the American Society for Mass Spectrome [Category] COVID19(2023년), [키워드] COVID-19 Liquid chromatography mass spectrometry Nirmatrelvir Ritonavir. [DOI] 10.1021/jasms.2c00204 PMC 바로가기 [Article Type] Case Reports
Spectroscopic methods for COVID-19 detection and early diagnosisArticle Published on 2022-09-222022-11-15 Journal: Virology Journal [Category] SARS, 치료기술, [키워드] caused coronavirus Coronavirus infection COVID-19 diagnosis of COVID-19 Early detection early diagnosis FIVE Fluorescence Fluorescence spectroscopy increase individual Infection infrared infrared spectroscopy limitation mass mass spectrometry pandemic Raman spectroscopy Raman spectroscopy. reduce reported SARS-CoV-2 Spread virus Weekly World Health Organization Wuhan, China [DOI] 10.1186/s12985-022-01867-2 PMC 바로가기
Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody ReactivityArticle Published on 2022-09-092022-11-15 Journal: ACS Infectious Diseases [Category] SARS, 진단, [키워드] acid antibody antibody reactivity carbohydrate cells Chinese hamster conserved defined domain embryonic kidney cell ENhance evaluated exhibited fucose generate glycoepitope glycoproteomics IgG less mammalian cells mass spectrometry modulated monosaccharides N-linked glycans Neutralizing antibodies produced Protein RBD reactivity Receptor binding domain receptor binding domain. reduced removal SARS-CoV-2 SARS-CoV-2 positive patients serum sample sialic acid Spike protein Structure the RBD the RBD protein the SARS-CoV-2 vaccine candidates Viral proteins [DOI] 10.1021/acsinfecdis.2c00155 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics proteomics. responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기